SURG-06CALCITRIOL SELECTIVELY ENHANCE QUALITY OF 5-AMINOLEVULINIC ACID METABOLIC IMAGING IN GLIOMAS
نویسندگان
چکیده
منابع مشابه
Multiphoton excitation fluorescence microscopy of 5-aminolevulinic acid induced fluorescence in experimental gliomas.
BACKGROUND AND OBJECTIVE The clinical usefulness of 5-ALA guided detection of tumor tissue has been demonstrated for a number of malignancies. However, current techniques of intraoperative detection of protoporphyrin IX fluorescence in situ do not offer subcellular resolution. Therefore, discrimination of non-specific 5-ALA induced fluorescence remains difficult. MATERIALS AND METHODS In this...
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Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) has become the main treatment modality in malignant gliomas. However unlike glioblastomas, there are inconsistent result about fluorescence status in WHO grade III gliomas. Here, we show that mutational status of IDH1 is linked to 5-ALA fluorescence. Using genetically engineered malignant glioma cells harboring wild type (U87MG-IDH...
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The need for novel, effective, and safe treatments for malignant glioma is obvious. Despite surgery, radiotherapy, and chemotherapy, the median survival time of patients with glioblastoma multiforme (World Health Organization Grade IV) still does not exceed 15 months. Patients with anaplastic astrocytoma (World Health Organization Grade III) have a slightly better prognosis. As a result of the ...
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BACKGROUND In patients operated for malignant glioma, 5-aminolevulinic acid (5-ALA)-induced fluorescence guidance is useful. However, we occasionally experience instances of non-visible fluorescence despite a histopathological diagnosis of high-grade glioma. We sought to identify factors that influence the intraoperative visualization of gliomas by their 5-ALA-induced fluorescence. PATIENTS A...
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Surgical resection is typically the first line of treatment for gliomas. However, the neurosurgeon faces a major challenge in achieving maximal resection in high-grade gliomas as these infiltrative tumors make it difficult to discern tumor margins from normal brain with conventional white-light microscopy alone. To aid in resection of these infiltrative tumors, fluorescence-guided surgery has g...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2015
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nov235.06